Volume III, the Clinical User's Manual, represents the updated International Version of this document. There are a number of variations of this material developed over 20 years. In order to conform to the regulatory requirements of each sovereign state, where the system may be utilized, we recommend that users adhere to these directives, obtain an IRB approval in the U.S. or permission from regulatory bodies in other countries, to apply the system for conditions not yet approved in that particular region. The manual is essential to both the understanding and application of Low Intensity Laser Therapy. It describes many of the technical aspects of the technology necessary to achieve optimal clinical outcomes. Moreover it provides guidelines for therapeutic application and describes the many combinations and permutations of protocols permissible in applying treatment. Careful study of this compilation of strategies is essential in order to achieve maximum effectiveness.